Paul (Eric Quizon) and Tessa Cepeda (Maricar Reyes) are loving parents to their daughter Sophie (Janella Salvador). Paul, a self-made man wants to give Sophie everything, while Tessa, a devotee of Sta. Teresa of Avila, instills on Sophie the value of mercy, love for others, a life of prayer.
But Tessa was gunned down in front of Sophie during a hold-up. Sophie was 10 years old when she lost her Nanay. Left to care for his daughter, Paul tries to give Sophie all the material things she wants. Sophie grows up as a proud and rich teenager, attached to gadgets and social networking sites, thinking that she has everything.
But when she turns 16, Paul dies in a car accident. Sophie questions God for all her misfortunes then she soon receives an answer from the Almighty himself.
Lost, alone, and penniless, Sophie calls to God by saying “Oh My G! Help me and I will do anything you say!” God then appears to Sophie in human form. Instead of giving back her material wealth, God sends Sophie on a mission—to find ANNE REYES. Sophie remembers that her father uttered the same request before he died. So, with reluctance, Sophie decides to obey God—thinking that maybe, just maybe, by obeying God, she will be rewarded by getting back all the things she lost. With the help of her long time tutor MRS. ROSE LUNA and her son, GABBY, Sophie looks for Anne Reyes. God also helps her by giving her clues in exchange of tasks, often dealing with different teenage issues. Through these tasks, Sophie eventually learns three important values— LOVE OF NEIGHBOR, HUMILITY, AND DETACHMENT.